3 days ago · In this trial, we want to evaluate whether a drug called Guanabenz is effective in slowing progression, stabilizing or even improving the brain white matter abnormalities in VWM. Guanabenz is an old and well-known medicine that has been used for decades for the treatment of high blood pressure. It has been approved by the FDA, the American ...Jul 9, 2017 · Posted 2017-07-06 1:30 PM. Subject: RE: Guanabenz. Extreme Veteran. Posts: 585. Location: Texas. I use the 20mg. .3- .8 cc for mine, most .5 cc. I've never used a full cc. I give it before I get on to warm up. I asked a vet about giving it orally and he said it won't hurt them but it might not be as effective. Nov 3, 2004 · The memo stated that Acepromazine, Detomidine, Reserpine, Fluphenazine and Guanabenz had been detected in equine samples. Detection of these drugs has proved difficult in the past, but improved ... The α 2-adrenergic receptor agonists clonidine, guanabenz, guanfacine, and methyldopa (Figure 8-3) effectively enter into the CNS and selectively stimulate α 2-adrenergic receptors in the brain. Methyldopa enters into the nerve terminal and is converted into the α 2 receptor–selective agonist α-methylnorepinephrine. α …Air-freight planes move anything that can be bought or sold. See how goods are shipped worldwide. Advertisement You can ship just about anything by air. Letters, packages, cars, ho...Air-freight planes move anything that can be bought or sold. See how goods are shipped worldwide. Advertisement You can ship just about anything by air. Letters, packages, cars, ho...What is guanabenz, and what is it used for? Guanabenz is a medication used to treat high blood pressure ( hypertension ), either as a single agent or with a …Discover all of our compounded equine medications. Visit The Good Pharma to browse, order and request our compounded preparations.From the Kentucky Derby to the local racetrack, there are a lot of ways to get interested in horse racing. Watching the races is fun, but once you see a few you probably want to ge...Jan 27, 2024 · Guanabenz has been available as a medicine to treat high blood pressure since the 1980s. In traumatic spinal cord injury, it is expected to work during the acute phase of the injury by reducing inflammation. It is thought to work by blocking enzymes called cyclo-oxygenase, lipoxygenase and nitric oxide synthase, which produce substances that are …1 day ago · Recurrent airway obstruction (RAO, also known as heaves, broken wind, and chronic airway reactivity) is the common respiratory disease of horses characterized by airway narrowing (bronchoconstriction), mucus production, and bronchospasm. Unlike IAD, horses with RAO are not normal at rest, and usually have an increased respiratory rate and/or cough. PEMF for Horses: Benefits, Precautions, Devices. by Richard Hoover. PEMF therapy has a wide range of applications, and brings numerous health benefits to those who use it. It can cure or alleviate many physical health conditions, but its power does not stop there. PEMF also affects our mind, and our psychological state. Her legacy has been reduced to tales of horses and sordid affairs, but the real story of Russia's longest reigning female leader is truly fascinating. Advertisement If persistent t... In horses, guanabenz has effects on the heart during intense exercise and may be performance enhancing. Before the drugs become widely used information about dose rates and safely must be known, these studies have augmented the information available. Horse hauling services provide a convenient way for horse owners to transport their horses from one location to another. Whether you’re moving your horse across town or across the ...Subject: RE: Guanabenz revisited. Expert. Posts: 4766. Location: Bandera, TX. All horses are a tad different you'll need to make minor adjustments to this. I use it about 1-1.5 hours out given IV. I just ordered the oral and will for the first time in my 35 or so years of training be trying it, I really hope I will like the oral …Jan 11, 2016 · Have you had any issues with it taking the run out of your horse?? ↑ Top ↓ Bottom: soonergirl98 Reg. Oct 2009: Posted 2016-01-10 7:36 PM Subject: RE: Guanabenz for Bleeders?? Expert. Posts: 2013 Location: Piedmont, OK: No. I have only heard of guanabenz being used to take the spook out of one. I know several …Jul 26, 2010 · Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist of the alpha-2 type that is used as an antihypertensive drug. It is used to treat high blood pressure (hypertension). Guanabenz lowers blood pressure by decreasing the levels of certain chemicals in the blood.Guanabenz (2,6-dichlorobenzylidene-amino-guanidine) is a centrally acting antihypertensive drug whose mechanism of action is via alpha2 adrenoceptors or, more likely, imidazoline …Jul 26, 2010 · Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist of the alpha-2 type that is used as an antihypertensive drug. It is used to treat high blood pressure (hypertension). Guanabenz lowers blood pressure by decreasing the levels of certain chemicals in the blood. Dec 5, 2003 ... Robb and Shuman were fined and suspended in Maryland last year when several of their horses tested positive for Guanabenz, a banned hypertension ...Sep 14, 2020 · A barrel horse is a short-distance sprinter, blasting top speed between the barrels. Maximal exertion is reached between the barrels as horses accelerate and decelerate in short bursts, which can require them to hold their breath at times and take deeper breaths at others. To turn a barrel at top speed, a horse must time its breathing correctly ... Jan 14, 2011 ... (i) The name of the horse, the horse's tattoo number, ... samples from any horses either in the horse's stall or within ... Guanabenz. Wytensin.Guanabenz has a 1-hour onset of antihypertensive action. The most commonly used initial dose of guanabenz is 4 mg 2× per day, titrated to a maximum of 64 mg daily. It is eliminated predominantly via hepatic biotransformation. Thus, unlike in the case of clonidine, guanabenz dose adjustment is not required in patients with renal failure but is ...Height (hh) 13.2. 'Poppy' was bred for versatility. Correct confirmation, athletic, and a great mind. Dam is a registered Canadian Warmblood ( TVR Gypsy Magic) and Sire…. View Details. $6,000 CAD.Mar 11, 2021 · However, these have not been directly studied for joint health in horses. This list is by no means exhaustive, as there are many supplements with purported benefits to joint health. Vitamin C, E, or A due to their antioxidant properties. These are typically paired with copper, selenium, or manganese, respectively.Targets include trazodone, fluphenazine, fluoxetine, reserpine, acepromazine, guanabenz, romifidine, xylazine, and detomidine. ... horses or to test non-equine ... Equine. For years, NexGen has been working with trusted professionals to offer pharmaceutical medicines for horses. Together, we have created powerful formulations to support health, performance and longevity in equines. NexGen covers everything equines may need, from medicines and treatments to supplements and vitamins. Guanabenz is used to treat high blood pressure. It is in a class of medications called centrally acting alpha 2A -adrenergic receptor agonists. Guanabenz works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body. High blood pressure is a common condition and when not treated, can ... Nov 3, 2004 · Fluphenazine and Guanabenz were two of five drugs named in an August 5th memo from the International Equestrian Federation's veterinary department to riders warning against the use of sedatives ...Guanabenz (Wytensin®) is an alpha-2 adrenergic receptor agonist marketed for use in humans as an anti-hypertensive agent. Recent reports indicate that …Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons …With the arrival of the Kentucky Derby and prime horse racing season, here's a guide for fans interesting in buying a racehorse. By clicking "TRY IT", I agree to receive newsletter...Advertise now. The sale of horses as a premium seller offers many advantages, such as an extensive statistical evaluation, an unlimited duration of your advertisements as well as a personal and equestrian-experienced service. When selling your horses, you can enter breed, type, suitability, sex, price and many other characteristics for the horses for sale …The LC-MS/MS results presented here form the basis of a confirmatory test for guanabenz in racing horses and may result in significant sanctions against the trainer of the horse. Guanabenz (2,6-dichlorobenzylidene-amino-guanidine) is a centrally acting antihypertensive drug whose mechanism of action is via alpha2 adrenoceptors or, more likely, imidazoline receptors.FOC dosing gun available with 200ml and 500ml packs. POM-VPS. Promo Pack includes: 2 x 500ml & 1 x Free 250ml Dectomax 10mg/ml Solution for Injection for Cattle and Sheep. Need help or advice? Contact us: Landline: 01582 842096. Mon - Fri: 9:00am - 5:00pm. Email: [email protected] days ago · The miracle of our work is not just that we can return a horse to physical health. With kindness, respect and endless love, we aim for nothing less than to see that horse become magnificent once again. Learn why Miracle Ranch is an equine sanctuary like no other. Our Approach. Rescue. Sanctuary.Nov 23, 2022 · Guanabenz is an antihypertensive drug - used to treat high blood pressure. In horseracing, it is a Class B, the second most serious kind. With that in mind, I give you the following recent rulings from the New Mexico Racing Commission: On Aug 13, trainer Aurelio Valdez's horse Reining Pesos tested positive for Guanabenz after… b). Furosemide (Salix) (except for horses that have raced on Furosemide) c). Procaine Penicillin d). Medroxyprogesterone e). Antihistamines f). Guanabenz g).14163 results. Find horse for sales online in our listings at Horseclicks. Search by breeds, disciplines, location and horses. We have over 200 breeds of ponies and horses for sale from registered breeders and horse lovers, if you're looking for the perfect trail riding horse, jumpers or an all rounder we have all the disciplines.Feb 21, 2020 · Guanabenz is an alpha agonist of the alpha-2 adrenergic receptor that can be used as a calming agent for horses with nervousness or anxiety. It is a long acting and reversible sedative and analgesic that can help improve the focus and manageability of racing and performance horses. Learn more about its uses, benefits and side effects from NexGen Pharmaceuticals. Aug 15, 2018 · Guanabenz is used to treat high blood pressure. It is in a class of medications called centrally acting alpha 2A -adrenergic receptor agonists. Guanabenz works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body. High blood pressure is a …May 5, 2022 · Intraperitoneal administration of Guanabenz for 25 days to obese rats resulted in a significant decrease in body weight compared to the baseline values (about 11% at a dose of 5 mg/kg). Both body weight and the amount of adipose tissue in the groups receiving Guanabenz decreased to the levels observed in the control rats fed only standard feed. You've probably heard the story about Catherine the Great and the horse -- it's a false piece of gossip that has lasted for more than 200 years. Learn what makes a conversation gos...Please direct all inquires to: United States Equestrian Federation®. Equine Drugs and Medications Program 956 King Avenue, Columbus, Ohio 43212 Phone 800.633.2472 Fax 614.299.7706 Email: [email protected] A commitment to the health, welfare and safety of the equine athlete is the common thread that binds all equestrian sport.Horses have hair and not fur. Although there is no difference between hair and fur, a horse’s coat is called hair because it is not dense enough for humans to use as garments. Hors...May 31, 2013 · Flossie Sellers - 06/08/2013 Health. Using Dormosedan Gel to Relieve Anxiety in Nervous Horses. Newsdate: Fri, 31 May 2013 - 8:22 am Location: KALAMAZOO, Michigan Some horses require sedating for clipping, dental treatment or shoeing, but calling a veterinarian each time is rather costly. Now the drug, Dormosedan Gel is being recommended by veterinarians …방문 중인 사이트에서 설명을 제공하지 않습니다.Jan 31, 2024 · Meclofenamic Acid (Arquel®): The maximum daily dose of meclofenamic acid is 0.5 gram for a 1,000 pound equine, which equals one (1) 500 milligram packet of granules. Meclofenamic acid should not be administered for more than five (5) consecutive days. 1,000 pound equine, which equals eight (8) 500 …Shop Phenylbutazone 20% injection for horses, 100ml, our veterinary compound specifically formulated for equines as a pain management solution from NexGenVetRx.com. Learn more about phenylbutazone 20% injection for horses, ... Guanabenz Guanabenz (also known as extraneal or adept) ...May 28, 2022 · Just how affective guanabenz is as a calming agent in performance horses was studied by researchers at the University of Florida. In their paper “The effect of adrenergic suppression induced by guanabenz administration on exercising Thoroughbred horses,” published in the August 2006 Equine Veterinary Journal Supplement , …Boo is a rescued 15-year-old male grizzly bear at Golden's Kicking Horse Mountain is British Columbia, Canada. Here's how you can pay him a visit. AS A MEDIA MEMBER I was lucky to ...May 5, 2022 · Intraperitoneal administration of Guanabenz for 25 days to obese rats resulted in a significant decrease in body weight compared to the baseline values (about 11% at a dose of 5 mg/kg). Both body weight and the amount of adipose tissue in the groups receiving Guanabenz decreased to the levels observed in the control rats fed only standard feed. The US Forest Service is gathering wild horses in California. Some will be sold to be eaten as meat. Animal advocates are suing to rein in the government. The Wild West is not so w...The New York Times beats the whole "multi-tasking reduces productivity" horse to death, reporting on another set of studies that show human brains slow down when they have to juggl...1 day ago · Recurrent airway obstruction (RAO, also known as heaves, broken wind, and chronic airway reactivity) is the common respiratory disease of horses characterized by airway narrowing (bronchoconstriction), mucus production, and bronchospasm. Unlike IAD, horses with RAO are not normal at rest, and usually have an increased respiratory rate and/or cough.Comment: Guanabenz is an antihypertensive drug. Marketed formulations may contain guanabenz acetate (PubChem CID 5702062). This entry shows the E isomer, as represented in the INN record for guanabenz. Ligand Activity Visualisation Charts. These are box plot that provide a unique visualisation ...Nov 23, 2022 · Guanabenz is an antihypertensive drug - used to treat high blood pressure. In horseracing, it is a Class B, the second most serious kind. With that in mind, I give you the following recent rulings from the New Mexico Racing Commission: On Aug 13, trainer Aurelio Valdez's horse Reining Pesos tested positive for Guanabenz after… Jul 6, 2017 · longer for guanabenz-treated horses, (P = 0.053). No significant effects of guanabenz administration were found for oxygen consumption, carbon dioxide production nor for plasma lactate, noradrenaline and ACTH concentrations. Conclusion: Guanabenz administration induced signs of adrenergic suppression including plasma cortisol andConnecting good people to good horses. Find My Right Horse. My Right Horse gathers hundreds of horses into one digital place, making it your one-stop destination for adoptable horses. Whether you’re looking for your next buckle-winning champion or your first-ever horse, your search starts here.Aug 1, 2006 · Results: Mean heart rate during the exercise period was lower in guanabenz‐treated horses (P=0.04). Mean concentrations of plasma cortisol (P=0.02) and adrenaline (P=0.03) were lower for guanabenz‐treated horses during the exercise period. Mean run time was slightly but not significantly longer for … As such, its identification in a postrace sample may result in significant sanctions against the trainer of the horse. The present study examined liquid chromatographic/tandem quadrupole mass spectrometric (LC-MS/MS) detection of guanabenz in serum samples from horses treated with guanabenz by rapid IV injection at 0.04 and 0.2 mg/kg. 1.800.786.4751. Indications. Guanabenz Acetate was developed to treat high blood pressure, but it is often used as a calming agent or sedative. It is commonly given to performance horses to relax them prior to competition via sterile injection. Multivitamin Iron Combo inj. # 81121-644. Aug 1, 2006 · RESULTS Mean heart rate during the exercise period was lower in guanabenz-treated horses (P = 0.04). Mean concentrations of plasma cortisol (P = 0.02) and adrenaline (P = 0.03) were lower for guanabenz-treated horses during the exercise period. Mean run time was slightly but not significantly longer for …Please direct all inquires to: United States Equestrian Federation®. Equine Drugs and Medications Program 956 King Avenue, Columbus, Ohio 43212 Phone 800.633.2472 Fax 614.299.7706 Email: [email protected] A commitment to the health, welfare and safety of the equine athlete is the common thread that binds all equestrian sport. Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species. As such, its identification in a postrace sample may result in significant sanctions against the trainer of the horse. The present study examined liquid chromatographic/tandem quadrupole mass spectrometric (LC-MS/MS) detection of guanabenz in serum samples from horses treated with guanabenz by rapid i.v. injection at 0.04 and 0.2 mg/kg. Advertisement It costs a tremendous amount of money to not only buy, but also maintain a race horse. There are stable fees, the salaries of grooms, trainers and farm managers, tran... Because guanabenz is extensively metabolized by the liver, it is recommended that dose increments be made cautiously in patients with liver disease. Dose Adjustments. Titrate dosage upwards in increments of 4 to 8 mg every 1 to 2 weeks. Patients with liver impairment should have dosage adjustments made cautiously. Precautions WDZVGELJXXEGPV-YIXHJXPBSA-N Guanabenz ... the term “subject” refers to animals such as mammals, including, but not limited to, primates (e.g., humans), cows, ...or, if you’re a licensed Veterinarian, we invite your to register with us here. The following list is just some of the chemicals BRD compounds into preparations. Please view the entire list upon logging in. If you are unable to find a specific compound, please contact us here or call us at (844) 447-5422.May 31, 2013 · Flossie Sellers - 06/08/2013 Health. Using Dormosedan Gel to Relieve Anxiety in Nervous Horses. Newsdate: Fri, 31 May 2013 - 8:22 am Location: KALAMAZOO, Michigan Some horses require sedating for clipping, dental treatment or shoeing, but calling a veterinarian each time is rather costly. Now the drug, Dormosedan Gel is being recommended by veterinarians …Her legacy has been reduced to tales of horses and sordid affairs, but the real story of Russia's longest reigning female leader is truly fascinating. Advertisement If persistent t...A baby horse is called a foal, though it may go by other names. If it’s still nursing from its mother, it may be called a suckling. After it weans from nursing, it may be called a ...Apr 25, 2018 · The AQHA issued a statement this month saying it had sanctioned Mozaun and Sarah McKibben after four horses tested positive for guanabenz, a depressant of the cardiovascular system. The association said the drug, forbidden per AQHA Rule VIO401.2, was found in four horses: His Royal Cat (by Boon A …5 days ago · Equine Medications. Precision Pharmacy takes pride in delivering the highest quality medications available to both veterinary practices and patients. All active ingredients come from FDA registered suppliers and we ensure that every step of the process, from ordering to delivery, is handled with the utmost care.DOI: 10.21836/pem20220607 Corpus ID: 253233486; Guanabenz in the horse – A preliminary report on clinical effects and comparison to clonidine and other alpha-2 adrenergic agonists @article{Lehner2022GuanabenzIT, title={Guanabenz in the horse – A preliminary report on clinical effects and comparison to clonidine and other alpha-2 …Apr 25, 2018 · The AQHA issued a statement this month saying it had sanctioned Mozaun and Sarah McKibben after four horses tested positive for guanabenz, a depressant of the cardiovascular system. The association said the drug, forbidden per AQHA Rule VIO401.2, was found in four horses: His Royal Cat (by Boon A …Doc Lane's offers veterinary pharmaceuticals for equine, pets, exotics, and wildlife. We have been in business over 10-years and are trusted by over 1,000 veterinarians in over 25 states.Nov 16, 2017 · Phenylbutazone (Bute) should not be given to a horse over a period of five consecutive days without a break to avoid test overages. In addition, the NCHA guideline example is based on a 1000 pound horse administered 1 cc (200mg.) IV per 100 lbs. of weight for a maximum dose of 2 gms. No more than 2 gms per 1000 lbs. should be administered in aPrior to the age of four, female horses are called fillies, and from age four and up, they are called mares. Female horses can also be called yearlings when they are between one an...May 26, 2019 · Guanabenz (GA) is an orally active α2-adrenergic agonist that has been used for many years for the treatment of hypertension. We recently described that GA is also active against both yeast and mammalian prions in an α2-adrenergic receptor-independent manner. These data suggest that this side-activity of GA could be explored for the …Nov 9, 2021 · Guanabenz may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions …May 22, 2023 · Guanabenz, guanfacine, clonidine, tizanidine, medetomidine, and dexmedetomidine are all α-2 agonists that vary in their potency and affinities for the various α-2 receptor subtypes. Clonidine, tizanidine, and dexmedetomidine are metabolized in the liver have received the greatest clinical use [ 14 ].Advertise now. The sale of horses as a premium seller offers many advantages, such as an extensive statistical evaluation, an unlimited duration of your advertisements as well as a personal and equestrian-experienced service. When selling your horses, you can enter breed, type, suitability, sex, price and many other characteristics for the horses for sale …Guanabenz has reportedly been administered to racing horses and is classified by the Association of Racing Commissioners International as a class 3 foreign …
GAINESVILLE,FL 32611. Performing Department. LARGE ANIMAL CLINICAL SCIENCES. Non Technical Summary. The potential deleterious or performance enhancing effects …. Pli legal
Guanabenz acetate, a selective α2-adrenoceptor stimulator used in the treatment of hypertension, binds at a high-affinity constant to a nuclear transcriptional coregulator, helicase with zinc finger 2 (Helz2) and inhibits Helz2-medaited steatosis in the liver; chronic oral administration of guanabenz acetate produces a dose-dependent inhibition of lipid …Aug 15, 2018 · Guanabenz is used to treat high blood pressure. It is in a class of medications called centrally acting alpha 2A -adrenergic receptor agonists. Guanabenz works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body. High blood pressure is a …Mar 11, 2021 · However, these have not been directly studied for joint health in horses. This list is by no means exhaustive, as there are many supplements with purported benefits to joint health. Vitamin C, E, or A due to their antioxidant properties. These are typically paired with copper, selenium, or manganese, respectively.Feb 21, 2020 · Guanabenz is an alpha agonist of the alpha-2 adrenergic receptor that can be used as a calming agent for horses with nervousness or anxiety. It is a long acting and reversible sedative and analgesic that can help improve the focus and manageability of racing and performance horses. Learn more about its uses, benefits and side effects from NexGen Pharmaceuticals. As of 2015, the cost of buying and maintaining one healthy horse for a year is at least $6,400, according the a University of Minnesota Horse Extension office. There are many facto...May 22, 2023 · Guanabenz, guanfacine, clonidine, tizanidine, medetomidine, and dexmedetomidine are all α-2 agonists that vary in their potency and affinities for the various α-2 receptor subtypes. Clonidine, tizanidine, and dexmedetomidine are metabolized in the liver have received the greatest clinical use [ 14 ].The aminoguanidine compound robenidine is widely used as an antibiotic for the control of coccidiosis, a protozoal infection in poultry and rabbits. Interestingly, robenidine is structurally similar to guanabenz (analogs), which are currently undergoing clinical trials as cytoprotective agents for the management of neurodegenerative diseases. Here we show …Methods and analyses Protocolised Management In Sepsis is a multicentre, randomised, double-blind, placebo-controlled phase II clinical trial with futility design. We will investigate clinical outcomes, safety, tolerability and biomarkers of neurodegeneration in patients with ALS treated with guanabenz or riluzole alone for 6 months. The primary aim is to test if …GAINESVILLE,FL 32611. Performing Department. LARGE ANIMAL CLINICAL SCIENCES. Non Technical Summary. The potential deleterious or performance enhancing effects …Guanabenz Acetate. Synonyms: WY-8678 Acetate. Catalog No.S4065 Purity: 99.60%. Guanabenz Acetate (WY-8678) is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively. Guanabenz Acetate Chemical Structure. The active ingredient in MARQUIS, ponazuril, crosses the blood brain barrier and targets the merozoite stages of the protozoa without affecting mammalian cells making it a safe choice for horses. 1 MARQUIS paste kills Sarcocystis neurona to prevent further damage to the central nervous system. To use an online neurological exam tool, visit ... Her legacy has been reduced to tales of horses and sordid affairs, but the real story of Russia's longest reigning female leader is truly fascinating. Advertisement If persistent t...horses treated with guanabenz by rapid IV in-jection at 0.04 and 0.2 mg/kg. Using a method adapted from previous workwith clenbuterol, the parent compound was detected in serum with an apparent ...Jun 3, 2014 · Cell viability of NRCM treated with doxorubicin (Dox; 100 nM) for 48 hours (D) or with thapsigargin (Tg; 100 nM) for 72 hours (E), with or without indicated concentrations of guanabenz. (n = 6–7); *P<0.05 **P<0.001. The above results indicated a protective guanabenz effect against drug-induced ER stress and cell death in cardiac myocytes.Guanabenz (Wytensin®) is an alpha-2 adrenergic receptor agonist marketed for use in humans as an anti-hypertensive agent. Recent reports indicate that guanabenz has been administered to horses in small doses (0.04 mg/kg) for its anti-hypertensive efects. See more.